cyp2c19 enzyme abundance information Search Results


94
Thermo Fisher snp cyp2c19 c 25986767 70
Genotype and allele frequencies of candidate drug metabolizing enzymes genes by hematologic toxicities, at the radiotherapy center, Tikur Anbessa specialized hospital, Addis Ababa University, Ethiopia.
Snp Cyp2c19 C 25986767 70, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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96
Thermo Fisher snp cyp2c19 c 27861809 10
Genotype and allele frequencies of candidate drug metabolizing enzymes genes by hematologic toxicities, at the radiotherapy center, Tikur Anbessa specialized hospital, Addis Ababa University, Ethiopia.
Snp Cyp2c19 C 27861809 10, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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99
Thermo Fisher gene exp cyp1a2 hs00167927 m1
Genotype and allele frequencies of candidate drug metabolizing enzymes genes by hematologic toxicities, at the radiotherapy center, Tikur Anbessa specialized hospital, Addis Ababa University, Ethiopia.
Gene Exp Cyp1a2 Hs00167927 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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94
Thermo Fisher c_25986767_70
Genotype and allele frequencies of candidate drug metabolizing enzymes genes by hematologic toxicities, at the radiotherapy center, Tikur Anbessa specialized hospital, Addis Ababa University, Ethiopia.
C 25986767 70, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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86
Thermo Fisher c_469857_10
Genotype and allele frequencies of candidate drug metabolizing enzymes genes by hematologic toxicities, at the radiotherapy center, Tikur Anbessa specialized hospital, Addis Ababa University, Ethiopia.
C 469857 10, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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93
Thermo Fisher snp cyp2c19 c 30634130 30
NeuroPGx panel (based on OpenArray™ technology).
Snp Cyp2c19 C 30634130 30, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Thermo Fisher gene exp cyp3a4 hs00604506 m1
NeuroPGx panel (based on OpenArray™ technology).
Gene Exp Cyp3a4 Hs00604506 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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86
Thermo Fisher snp cyp2c19 c 469857 10
NeuroPGx panel (based on OpenArray™ technology).
Snp Cyp2c19 C 469857 10, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Thermo Fisher c__27861810_10
NeuroPGx panel (based on OpenArray™ technology).
C 27861810 10, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Simcyp simcyp simulator v21
NeuroPGx panel (based on OpenArray™ technology).
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Thermo Fisher snp cyp2c19 c 30634136 10
NeuroPGx panel (based on OpenArray™ technology).
Snp Cyp2c19 C 30634136 10, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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98
Thermo Fisher gene exp cyp2c19 hs00426380 m1
Relative cytochrome P450 mRNA expression in duodenum, jejunum and ileum. The observed expression pattern of cytochrome P450 mRNAs was similar among duodenum, jejunum and ileum regions with high expression for CYP3A4, CYP2C9, <t>CYP2C19</t> and CYP2J2. CYP1A2, CYP2A6 and CYP3A7 were not found in all samples along the small intestine. Others: cytochromes P450 with a relative mRNA expression levels <1% are regrouped into 1 group referred as Others. Other cytochromes P450 duodenum: CYP1B1, CYP2B6, <t>CYP2C8,</t> CYP2D6, CYP2E1 and CYP4A11. Other cytochromes P450 jejunum: CYP1A1, CYP1B1, CYP2B6, CYP2C8, CYP2D6, CYP2E1 and CYP4A11. Other cytochromes P450 ileum: CYP1A1, CYP2C8, CYP2D6, CYP2E1 and CYP4A11
Gene Exp Cyp2c19 Hs00426380 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Genotype and allele frequencies of candidate drug metabolizing enzymes genes by hematologic toxicities, at the radiotherapy center, Tikur Anbessa specialized hospital, Addis Ababa University, Ethiopia.

Journal: Frontiers in Pharmacology

Article Title: CYP2J2 ∗ 7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients

doi: 10.3389/fphar.2019.00481

Figure Lengend Snippet: Genotype and allele frequencies of candidate drug metabolizing enzymes genes by hematologic toxicities, at the radiotherapy center, Tikur Anbessa specialized hospital, Addis Ababa University, Ethiopia.

Article Snippet: In brief genotyping was performed using TaqMan ® drug metabolism genotyping assay reagents for allelic discrimination (Applied Biosystems Genotyping Assays) with the following ID numbers for each SNP: C__7817765_60 for CYP2B6 ∗ 6 (c.516G4T, rs3745274), C__26201809_30 for CYP3A5 ∗ 3 (c.6986A4G, rs776746), C__25625805_10 for CYP2C9 ∗ 2 (rs1799853), C__27104892_10 for CYP2C9 ∗ 3 (rs1057910), C__25986767_70 for CYP2C19 ∗ 2 (rs4244285), C__27861809_10 for CYP2C19 ∗ 3 (rs4986893), C_9581699_80 for CYP2J2 ∗ 7 (rs890293), C_8890131_30 for POR ∗ 28 (rs1057868), and C__11711730_20 for ABCB1 (rs3842).

Techniques:

Cox proportional hazard regression results for incidence of grade 3 or 4 hematologic toxicity.

Journal: Frontiers in Pharmacology

Article Title: CYP2J2 ∗ 7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients

doi: 10.3389/fphar.2019.00481

Figure Lengend Snippet: Cox proportional hazard regression results for incidence of grade 3 or 4 hematologic toxicity.

Article Snippet: In brief genotyping was performed using TaqMan ® drug metabolism genotyping assay reagents for allelic discrimination (Applied Biosystems Genotyping Assays) with the following ID numbers for each SNP: C__7817765_60 for CYP2B6 ∗ 6 (c.516G4T, rs3745274), C__26201809_30 for CYP3A5 ∗ 3 (c.6986A4G, rs776746), C__25625805_10 for CYP2C9 ∗ 2 (rs1799853), C__27104892_10 for CYP2C9 ∗ 3 (rs1057910), C__25986767_70 for CYP2C19 ∗ 2 (rs4244285), C__27861809_10 for CYP2C19 ∗ 3 (rs4986893), C_9581699_80 for CYP2J2 ∗ 7 (rs890293), C_8890131_30 for POR ∗ 28 (rs1057868), and C__11711730_20 for ABCB1 (rs3842).

Techniques:

NeuroPGx panel (based on OpenArray™ technology).

Journal: Journal of Personalized Medicine

Article Title: Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders

doi: 10.3390/jpm11090851

Figure Lengend Snippet: NeuroPGx panel (based on OpenArray™ technology).

Article Snippet: , , *8 , 12711T > C , rs41291556 , C__30634130_30 , c.358T > C , p.Trp120Arg.

Techniques: Variant Assay

Selected drugs and CYP genes associated.

Journal: Journal of Personalized Medicine

Article Title: Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders

doi: 10.3390/jpm11090851

Figure Lengend Snippet: Selected drugs and CYP genes associated.

Article Snippet: , , *8 , 12711T > C , rs41291556 , C__30634130_30 , c.358T > C , p.Trp120Arg.

Techniques:

Selected SNPs. Frequency of detectable alleles have been calculated according to population data [ <xref ref-type= 5 ]. Abbr.: SSA = Sub-Saharan African; AA/AC = African American/Afro-Carribbean; Eur = European; NE = Near Eastern; EA = East Asian; CSA = Central/South Asian; Ame = American; Lat = Latino; Oce = Oceanian; AF = allele frequency." width="100%" height="100%">

Journal: Journal of Personalized Medicine

Article Title: Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders

doi: 10.3390/jpm11090851

Figure Lengend Snippet: Selected SNPs. Frequency of detectable alleles have been calculated according to population data [ 5 ]. Abbr.: SSA = Sub-Saharan African; AA/AC = African American/Afro-Carribbean; Eur = European; NE = Near Eastern; EA = East Asian; CSA = Central/South Asian; Ame = American; Lat = Latino; Oce = Oceanian; AF = allele frequency.

Article Snippet: , , *8 , 12711T > C , rs41291556 , C__30634130_30 , c.358T > C , p.Trp120Arg.

Techniques:

Comparison between guidelines (CPIC and DPWG) and drug labels (FDA and EMA/AIFA) for pharmacogenetic data. Abbr.: FDA = Food and Drug Administration; EMA = European Medicines Agency; AIFA = Italian Medicines Agency; noRec = no recommendation reported in the guideline; N = no information about CYP phenotypes; Y = the label reports information about CYP phenotypes, with or without suggestion to investigate CYP genotype; NA: not approved.

Journal: Journal of Personalized Medicine

Article Title: Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders

doi: 10.3390/jpm11090851

Figure Lengend Snippet: Comparison between guidelines (CPIC and DPWG) and drug labels (FDA and EMA/AIFA) for pharmacogenetic data. Abbr.: FDA = Food and Drug Administration; EMA = European Medicines Agency; AIFA = Italian Medicines Agency; noRec = no recommendation reported in the guideline; N = no information about CYP phenotypes; Y = the label reports information about CYP phenotypes, with or without suggestion to investigate CYP genotype; NA: not approved.

Article Snippet: , , *8 , 12711T > C , rs41291556 , C__30634130_30 , c.358T > C , p.Trp120Arg.

Techniques: Comparison

Relative cytochrome P450 mRNA expression in duodenum, jejunum and ileum. The observed expression pattern of cytochrome P450 mRNAs was similar among duodenum, jejunum and ileum regions with high expression for CYP3A4, CYP2C9, CYP2C19 and CYP2J2. CYP1A2, CYP2A6 and CYP3A7 were not found in all samples along the small intestine. Others: cytochromes P450 with a relative mRNA expression levels <1% are regrouped into 1 group referred as Others. Other cytochromes P450 duodenum: CYP1B1, CYP2B6, CYP2C8, CYP2D6, CYP2E1 and CYP4A11. Other cytochromes P450 jejunum: CYP1A1, CYP1B1, CYP2B6, CYP2C8, CYP2D6, CYP2E1 and CYP4A11. Other cytochromes P450 ileum: CYP1A1, CYP2C8, CYP2D6, CYP2E1 and CYP4A11

Journal: British Journal of Clinical Pharmacology

Article Title: Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine

doi: 10.1111/bcp.13908

Figure Lengend Snippet: Relative cytochrome P450 mRNA expression in duodenum, jejunum and ileum. The observed expression pattern of cytochrome P450 mRNAs was similar among duodenum, jejunum and ileum regions with high expression for CYP3A4, CYP2C9, CYP2C19 and CYP2J2. CYP1A2, CYP2A6 and CYP3A7 were not found in all samples along the small intestine. Others: cytochromes P450 with a relative mRNA expression levels <1% are regrouped into 1 group referred as Others. Other cytochromes P450 duodenum: CYP1B1, CYP2B6, CYP2C8, CYP2D6, CYP2E1 and CYP4A11. Other cytochromes P450 jejunum: CYP1A1, CYP1B1, CYP2B6, CYP2C8, CYP2D6, CYP2E1 and CYP4A11. Other cytochromes P450 ileum: CYP1A1, CYP2C8, CYP2D6, CYP2E1 and CYP4A11

Article Snippet: The analysed cytochromes P450 were: CYP1A1 (Hs01054796_g1), CYP1A2 (Hs00167927_m1), CYP1B1 (Hs00164383_m1), CYP2A6 (Hs00868409_s1), CYP2B6 (Hs04183483_g1), CYP2C8 (Hs00946140_g1), CYP2C9 (Hs00426397_m1), CYP2C19 (Hs00426380_m1), CYP2D6 (Hs02576167_m1), CYP2E1 (Hs00559368_m1), CYP2J2 (Hs00951113_m1), CYP3A4 (Hs00604506_m1), CYP3A5 (Hs01070905_m1), CYP3A7 (Hs00426361_m1), CYP4A11 (Hs00167961_m1), CYP4F2 (Hs00426608_m1) and CYP4F12 (Hs02515808_s1).

Techniques: Expressing

Estimated in vitro kinetic parameters for  cytochrome P450  probes determined in proximal jejunum and mid‐jejunum (n = 9)

Journal: British Journal of Clinical Pharmacology

Article Title: Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine

doi: 10.1111/bcp.13908

Figure Lengend Snippet: Estimated in vitro kinetic parameters for cytochrome P450 probes determined in proximal jejunum and mid‐jejunum (n = 9)

Article Snippet: The analysed cytochromes P450 were: CYP1A1 (Hs01054796_g1), CYP1A2 (Hs00167927_m1), CYP1B1 (Hs00164383_m1), CYP2A6 (Hs00868409_s1), CYP2B6 (Hs04183483_g1), CYP2C8 (Hs00946140_g1), CYP2C9 (Hs00426397_m1), CYP2C19 (Hs00426380_m1), CYP2D6 (Hs02576167_m1), CYP2E1 (Hs00559368_m1), CYP2J2 (Hs00951113_m1), CYP3A4 (Hs00604506_m1), CYP3A5 (Hs01070905_m1), CYP3A7 (Hs00426361_m1), CYP4A11 (Hs00167961_m1), CYP4F2 (Hs00426608_m1) and CYP4F12 (Hs02515808_s1).

Techniques: In Vitro

Relative levels of mRNA expression for 17  cytochrome P450  isoforms in 10 intestinal subsections (2 ‐∆∆CT ). Results are expressed as mean ± standard deviation (* P value <.05 compared between subsections)

Journal: British Journal of Clinical Pharmacology

Article Title: Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine

doi: 10.1111/bcp.13908

Figure Lengend Snippet: Relative levels of mRNA expression for 17 cytochrome P450 isoforms in 10 intestinal subsections (2 ‐∆∆CT ). Results are expressed as mean ± standard deviation (* P value <.05 compared between subsections)

Article Snippet: The analysed cytochromes P450 were: CYP1A1 (Hs01054796_g1), CYP1A2 (Hs00167927_m1), CYP1B1 (Hs00164383_m1), CYP2A6 (Hs00868409_s1), CYP2B6 (Hs04183483_g1), CYP2C8 (Hs00946140_g1), CYP2C9 (Hs00426397_m1), CYP2C19 (Hs00426380_m1), CYP2D6 (Hs02576167_m1), CYP2E1 (Hs00559368_m1), CYP2J2 (Hs00951113_m1), CYP3A4 (Hs00604506_m1), CYP3A5 (Hs01070905_m1), CYP3A7 (Hs00426361_m1), CYP4A11 (Hs00167961_m1), CYP4F2 (Hs00426608_m1) and CYP4F12 (Hs02515808_s1).

Techniques: Expressing, Standard Deviation

 Cytochrome P450  activities measured in 5 different subsections along the human small intestine ( n = 9; except for the duodenum where n = 7). Incubations were performed at substrate saturation

Journal: British Journal of Clinical Pharmacology

Article Title: Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine

doi: 10.1111/bcp.13908

Figure Lengend Snippet: Cytochrome P450 activities measured in 5 different subsections along the human small intestine ( n = 9; except for the duodenum where n = 7). Incubations were performed at substrate saturation

Article Snippet: The analysed cytochromes P450 were: CYP1A1 (Hs01054796_g1), CYP1A2 (Hs00167927_m1), CYP1B1 (Hs00164383_m1), CYP2A6 (Hs00868409_s1), CYP2B6 (Hs04183483_g1), CYP2C8 (Hs00946140_g1), CYP2C9 (Hs00426397_m1), CYP2C19 (Hs00426380_m1), CYP2D6 (Hs02576167_m1), CYP2E1 (Hs00559368_m1), CYP2J2 (Hs00951113_m1), CYP3A4 (Hs00604506_m1), CYP3A5 (Hs01070905_m1), CYP3A7 (Hs00426361_m1), CYP4A11 (Hs00167961_m1), CYP4F2 (Hs00426608_m1) and CYP4F12 (Hs02515808_s1).

Techniques: Activity Assay