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Image Search Results
Journal: Frontiers in Pharmacology
Article Title: CYP2J2 ∗ 7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients
doi: 10.3389/fphar.2019.00481
Figure Lengend Snippet: Genotype and allele frequencies of candidate drug metabolizing enzymes genes by hematologic toxicities, at the radiotherapy center, Tikur Anbessa specialized hospital, Addis Ababa University, Ethiopia.
Article Snippet: In brief genotyping was performed using TaqMan ® drug metabolism genotyping assay reagents for allelic discrimination (
Techniques:
Journal: Frontiers in Pharmacology
Article Title: CYP2J2 ∗ 7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients
doi: 10.3389/fphar.2019.00481
Figure Lengend Snippet: Cox proportional hazard regression results for incidence of grade 3 or 4 hematologic toxicity.
Article Snippet: In brief genotyping was performed using TaqMan ® drug metabolism genotyping assay reagents for allelic discrimination (
Techniques:
Journal: Journal of Personalized Medicine
Article Title: Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders
doi: 10.3390/jpm11090851
Figure Lengend Snippet: NeuroPGx panel (based on OpenArray™ technology).
Article Snippet: , , *8 , 12711T > C , rs41291556 ,
Techniques: Variant Assay
Journal: Journal of Personalized Medicine
Article Title: Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders
doi: 10.3390/jpm11090851
Figure Lengend Snippet: Selected drugs and CYP genes associated.
Article Snippet: , , *8 , 12711T > C , rs41291556 ,
Techniques:
5 ]. Abbr.: SSA = Sub-Saharan African; AA/AC = African American/Afro-Carribbean; Eur = European; NE = Near Eastern; EA = East Asian; CSA = Central/South Asian; Ame = American; Lat = Latino; Oce = Oceanian; AF = allele frequency." width="100%" height="100%">
Journal: Journal of Personalized Medicine
Article Title: Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders
doi: 10.3390/jpm11090851
Figure Lengend Snippet: Selected SNPs. Frequency of detectable alleles have been calculated according to population data [
Article Snippet: , , *8 , 12711T > C , rs41291556 ,
Techniques:
Journal: Journal of Personalized Medicine
Article Title: Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders
doi: 10.3390/jpm11090851
Figure Lengend Snippet: Comparison between guidelines (CPIC and DPWG) and drug labels (FDA and EMA/AIFA) for pharmacogenetic data. Abbr.: FDA = Food and Drug Administration; EMA = European Medicines Agency; AIFA = Italian Medicines Agency; noRec = no recommendation reported in the guideline; N = no information about CYP phenotypes; Y = the label reports information about CYP phenotypes, with or without suggestion to investigate CYP genotype; NA: not approved.
Article Snippet: , , *8 , 12711T > C , rs41291556 ,
Techniques: Comparison
Journal: British Journal of Clinical Pharmacology
Article Title: Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine
doi: 10.1111/bcp.13908
Figure Lengend Snippet: Relative cytochrome P450 mRNA expression in duodenum, jejunum and ileum. The observed expression pattern of cytochrome P450 mRNAs was similar among duodenum, jejunum and ileum regions with high expression for CYP3A4, CYP2C9, CYP2C19 and CYP2J2. CYP1A2, CYP2A6 and CYP3A7 were not found in all samples along the small intestine. Others: cytochromes P450 with a relative mRNA expression levels <1% are regrouped into 1 group referred as Others. Other cytochromes P450 duodenum: CYP1B1, CYP2B6, CYP2C8, CYP2D6, CYP2E1 and CYP4A11. Other cytochromes P450 jejunum: CYP1A1, CYP1B1, CYP2B6, CYP2C8, CYP2D6, CYP2E1 and CYP4A11. Other cytochromes P450 ileum: CYP1A1, CYP2C8, CYP2D6, CYP2E1 and CYP4A11
Article Snippet: The analysed cytochromes P450 were: CYP1A1 (Hs01054796_g1), CYP1A2 (Hs00167927_m1), CYP1B1 (Hs00164383_m1), CYP2A6 (Hs00868409_s1), CYP2B6 (Hs04183483_g1), CYP2C8 (Hs00946140_g1), CYP2C9 (Hs00426397_m1), CYP2C19 (
Techniques: Expressing
Journal: British Journal of Clinical Pharmacology
Article Title: Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine
doi: 10.1111/bcp.13908
Figure Lengend Snippet: Estimated in vitro kinetic parameters for cytochrome P450 probes determined in proximal jejunum and mid‐jejunum (n = 9)
Article Snippet: The analysed cytochromes P450 were: CYP1A1 (Hs01054796_g1), CYP1A2 (Hs00167927_m1), CYP1B1 (Hs00164383_m1), CYP2A6 (Hs00868409_s1), CYP2B6 (Hs04183483_g1), CYP2C8 (Hs00946140_g1), CYP2C9 (Hs00426397_m1), CYP2C19 (
Techniques: In Vitro
Journal: British Journal of Clinical Pharmacology
Article Title: Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine
doi: 10.1111/bcp.13908
Figure Lengend Snippet: Relative levels of mRNA expression for 17 cytochrome P450 isoforms in 10 intestinal subsections (2 ‐∆∆CT ). Results are expressed as mean ± standard deviation (* P value <.05 compared between subsections)
Article Snippet: The analysed cytochromes P450 were: CYP1A1 (Hs01054796_g1), CYP1A2 (Hs00167927_m1), CYP1B1 (Hs00164383_m1), CYP2A6 (Hs00868409_s1), CYP2B6 (Hs04183483_g1), CYP2C8 (Hs00946140_g1), CYP2C9 (Hs00426397_m1), CYP2C19 (
Techniques: Expressing, Standard Deviation
Journal: British Journal of Clinical Pharmacology
Article Title: Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine
doi: 10.1111/bcp.13908
Figure Lengend Snippet: Cytochrome P450 activities measured in 5 different subsections along the human small intestine ( n = 9; except for the duodenum where n = 7). Incubations were performed at substrate saturation
Article Snippet: The analysed cytochromes P450 were: CYP1A1 (Hs01054796_g1), CYP1A2 (Hs00167927_m1), CYP1B1 (Hs00164383_m1), CYP2A6 (Hs00868409_s1), CYP2B6 (Hs04183483_g1), CYP2C8 (Hs00946140_g1), CYP2C9 (Hs00426397_m1), CYP2C19 (
Techniques: Activity Assay